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The RFS advantage of the combination was uniform across biomarker-defined subgroups, encompassing both TMB-high and TMB-non-high, PD-L1-positive and negative, as well as ctDNA-negative individuals

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Confronted with the challenge of ferroptosis, GCH1 ensures a stable supply of folate, promoting the rapid recovery and regeneration of damaged skin cells, thereby combating the cell damage caused by an imbalance of iron ions (101)

These effects are achieved by suppressing tumour growth, inducing apoptosis via activation of caspase 3, anti-angiogenesis through VEGF inhibition, and sensitising several chemotherapeutic agents to both in vitro and in vivo drug resistance mechanisms (60)

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